منابع مشابه
Nucleic acid chemistry
Since the discovery of the structure of the DNA double helix in 1953 by Watson and Crick [1], we know that DNA is of critical importance, carrying the genetic information for all living organisms. Only a few years later appeared the first reports on the chemical synthesis of oligonucleotides with a natural 3'-5' phosphodiester linker by Michelsen and Todd [2]. It took another two decades until ...
متن کاملEarly nucleic acid chemistry.
,g i:. The contemporary biochemist, perusing the publications of the past century, may easily be misled into some arrogance when sorting out the erroneous data and leads, the slow progress and the primitive reports of that early period. However, when recalling the limited techniques and the lack of facilities at the early stages of biochemistry, he will change his mind. The difficulties encount...
متن کاملNucleic Acid i-Motif Structures in Analytical Chemistry.
Under the appropriate experimental conditions of pH and temperature, cytosine-rich segments in DNA or RNA sequences may produce a characteristic folded structure known as an i-motif. Besides its potential role in vivo, which is still under investigation, this structure has attracted increasing interest in other fields due to its sharp, fast and reversible pH-driven conformational changes. This ...
متن کامل2 An Overview of Nucleic Acid Chemistry , Structure , and Function
Chemists and early biochemists determined the essential building blocks of living cells and characterized their chemical nature. Among these building blocks were nucleic acids, longchain polymers composed of nucleotides. Nucleic acids were named based partly on their chemical properties and partly on the observation that they represent a major constituent of the cell nucleus. That nucleic acids...
متن کاملLanthanide Chelates as a Tool in Nucleic Acid Chemistry
The potentiality of lanthanide chelates as photoluminescent markers and cleaving agents of nucleic acids is discussed, the main emphasis being on the chelates derived from aromatic nitrogen bases.
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ژورنال
عنوان ژورنال: Nature
سال: 1966
ISSN: 0028-0836,1476-4687
DOI: 10.1038/2121020c0